Journal
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Volume 55, Issue 1, Pages 39-46Publisher
WILEY
DOI: 10.1111/j.1574-695X.2008.00495.x
Keywords
macrophage; Mycobacterium bovis Bacillus Calmette-Guerin (BCG); Mycobacterium leprae; GM-CSF; T-cell activation; interleukin-10
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Funding
- Japanese Red Cross Society
- Ministry of Health, Labour, and Welfare of Japan
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The potential of Mycobacterium bovis Bacillus Calmette-Guerin (BCG) needs to be augmented to efficiently activate CD4(+) T cells through macrophages. Mycobacterium leprae-derived recombinant major membrane protein (MMP)-II induced GM-CSF production from macrophages. A recombinant BCG-SM that secretes MMP-II more efficiently produced GM-CSF and activated interferon (IFN)-gamma-producing CD4(+) T cells than did vector control BCG when infected with macrophages. The T-cell activation by BCG-SM was dependent on the GM-CSF production by macrophages. Interleukin (IL)-10 production by macrophages stimulated with M. leprae was inhibited in a GM-CSF-dependent manner when the precursor monocytes were infected with BCG-SM. BCG inducing GM-CSF production was effective in macrophage-mediated T-cell activation partially through IL-10 inhibition.
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