Journal
FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY
Volume 56, Issue 3, Pages 248-252Publisher
WILEY
DOI: 10.1111/j.1574-695X.2009.00572.x
Keywords
Enterobacter cloacae; cytotoxicity; type III secretion system
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We examined 55 Enterobacter cloacae isolates from clinical specimens for the production of cytotonic and cytotoxic toxins and the presence of the type III secretion system (TTSS). Twelve isolates (22%) revealed cytotoxic activity that caused destruction of Vero cells, whereas 28 (51%) strains induced lysis of the murine macrophage J774 cell line. TTSS genes were present in 27% of the isolates. The results indicated that these bacteria may destroy phagocytes and epithelial cells, which may lead to spread within the host.
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