Journal
FEBS LETTERS
Volume 592, Issue 22, Pages 3696-3707Publisher
WILEY
DOI: 10.1002/1873-3468.13252
Keywords
embryo implantation; endometrial receptivity; sLeX; ST3Gal3
Funding
- National Natural Science Foundation of China [31670810, 31770857]
- Postdoctoral Science Foundation of China [S2018M630292]
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The receptive uterine endometrium specifically expresses certain glycosyltransferases, and the corresponding oligosaccharides play important roles in accepting the embryo. The sialyltransferase beta-galactoside-alpha 2,3-sialyltransferase III (ST3Gal3) is the key enzyme responsible for sialyl Lewis X (sLeX) oligosaccharide biosynthesis, but the expression and function of ST3Gal3 in the receptive endometrium is still elusive. Here, we found that human endometrial tissues at secretory phase expressed a 4-fold higher ST3Gal3 level relative to the tissues at proliferative phase. Meanwhile, downregulation of ST3Gal3 or sLeX epitope blockage significantly impaired the receptive ability of human endometrial RL95-2 cells to trophoblastic cells in vitro and inhibited implantation in pregnant mice. This study suggests that ST3Gal3 facilitates endometrial receptivity through increasing sLeX oligosaccharide, which gives a better understanding of the glycobiology of implantation.
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