Journal
FEBS LETTERS
Volume 588, Issue 14, Pages 2185-2197Publisher
WILEY
DOI: 10.1016/j.febslet.2014.05.029
Keywords
Poly(A) polymerase (PAP); Canonical PAP; PAP isoforms; PAP alpha; Star-PAP; PI4,5P(2); PIPKI alpha; CKI; Polyadenylation; Uridylation; 3'-end processing; Oxidative stress
Funding
- Wellcome Trust-India Alliance [IA/I/1/505008]
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Almost all eukaryotic mRNAs acquire a poly(A) tail at the 3'-end by a concerted RNA processing event: cleavage and polyadenylation. The canonical PAP, PANE, was considered the only nuclear PAP involved in general polyadenylation of mRNAs. A phosphoinositide-modulated nuclear PAP, Star-PAP, was then reported to regulate a select set of mRNAs in the cell. In addition, several non-canonical PAPs have been identified with diverse cellular functions. Further, canonical PAP itself exists in multiple isoforms thus illustrating the diversity of PAPs. In this review, we compare two nuclear PAPs, Star-PAP and PAP alpha with a general overview of PAP diversity in the cell. Emerging evidence suggests distinct niches of target pre-mRNAs for the two PAPs and that modulation of these PAPs regulates distinct cellular functions. (C) 2014 The Author. Published by Elsevier B.V.
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