Journal
FEBS LETTERS
Volume 588, Issue 5, Pages 829-835Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.01.046
Keywords
End-binding protein 1; Adenomatous polyposis coli; Colon cancer; Field carcinogenesis; Sub-diffractional structure
Funding
- NIH [U01CA111257, R01CA128641, R01CA165309, R01CA156186]
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End-binding protein (EB1) is a microtubule protein that binds to the tumor suppressor adenomatous polyposis coli (APC). While EB1 is implicated as a potential oncogene, its role in cancer progression is unknown. Therefore, we analyzed EB1/APC expression at the earliest stages of colorectal carcinogenesis and in the uninvolved mucosa (field effect'') of human and animal tissue. We also performed siRNA-knockdown in colon cancer cell lines. EB1 is up-regulated in early and field carcinogenesis in the colon, and the cellular/nano-architectural effect of EB1 knockdown depended on the genetic context. Thus, dysregulation of EB1 is an important early event in colon carcinogenesis. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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