Journal
FEBS LETTERS
Volume 588, Issue 22, Pages 4214-4222Publisher
WILEY
DOI: 10.1016/j.febslet.2014.09.024
Keywords
Risk factor; Autoimmunity; CNS; Gut; Microbiome
Funding
- National MS Society (NMSS) [CA 1027A1/3]
- NIH [R41 AI110170/AI/NIAID, R56 AI098282/AI/NIAID]
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Humans are colonized after birth by microbial organisms that form a heterogeneous community, collectively termed microbiota. The genomic pool of this macro-community is named microbiome. The gut microbiota is essential for the complete development of the immune system, representing a binary network in which the microbiota interact with the host providing important immune and physiologic function and conversely the bacteria protect themselves from host immune defense. Alterations in the balance of the gut microbiome due to a combination of environmental and genetic factors can now be associated with detrimental or protective effects in experimental autoimmune diseases. These gut microbiome alterations can unbalance the gastrointestinal immune responses and influence distal effector sites leading to CNS disease including both demyelination and affective disorders. The current range of risk factors for MS includes genetic makeup and environmental elements. Of interest to this review is the consistency between this range of MS risk factors and the gut microbiome. We postulate that the gut microbiome serves as the niche where different MS risk factors merge, thereby influencing the disease process. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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