Journal
FEBS LETTERS
Volume 588, Issue 16, Pages 2693-2703Publisher
WILEY
DOI: 10.1016/j.febslet.2014.02.006
Keywords
Angiomotin; Motin; Angiomotin-like 1; Angiomotin-like 2; Hippo; YAP; NF2; Merlin
Funding
- NCI NIH HHS [R01 CA124495] Funding Source: Medline
- NINDS NIH HHS [R01 NS077952] Funding Source: Medline
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Angiomotins were originally identified as angiostatin binding proteins and implicated in the regulation of endothelial cell migration. Recent studies have shed light on the role of Angiomotins and other members of the Motin protein family in epithelial cells and in pathways directly linked to the pathogenesis of cancer. In particular, Motins have been shown to play a role in signaling pathways regulated by small G-proteins and the Hippo-YAP pathway. In this review the role of the Motin protein family in these signaling pathways will be described and open questions will be discussed. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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