Related references
Note: Only part of the references are listed.A Targeting Modality for Destruction of RNA Polymerase I that Possesses Anticancer Activity
Karita Peltonen et al.
CANCER CELL (2014)
sROS-dependent activation of JNK converts p53 into an efficient inhibitor of oncogenes leading to robust apoptosis
Y. Shi et al.
CELL DEATH AND DIFFERENTIATION (2014)
Targeting MDM2-p53 Interaction for Cancer Therapy: Are We There Yet?
S. Nag et al.
CURRENT MEDICINAL CHEMISTRY (2014)
Activation of a promyelocytic leukemia-tumor protein 53 axis underlies acute promyelocytic leukemia cure
Julien Ablain et al.
NATURE MEDICINE (2014)
Drugging the p53 pathway: understanding the route to clinical efficacy
Khoo Kian Hoe et al.
NATURE REVIEWS DRUG DISCOVERY (2014)
Loss of p53 in Enterocytes Generates an Inflammatory Microenvironment Enabling Invasion and Lymph Node Metastasis of Carcinogen-Induced Colorectal Tumors
Sarah Schwitalla et al.
CANCER CELL (2013)
Non-Cell-Autonomous Tumor Suppression by p53
Amaia Lujambio et al.
CELL (2013)
Molecular Pathways: Targeting Mdm2 and Mdm4 in Cancer Therapy
Qin Li et al.
CLINICAL CANCER RESEARCH (2013)
Dual Targeting of Wild-Type and Mutant p53 by Small Molecule RITA Results in the Inhibition of N-Myc and Key Survival Oncogenes and Kills Neuroblastoma Cells In Vivo and In Vitro
Mikhail Burmakin et al.
CLINICAL CANCER RESEARCH (2013)
Global genomic profiling reveals an extensive p53-regulated autophagy program contributing to key p53 responses
Daniela Kenzelmann Broz et al.
GENES & DEVELOPMENT (2013)
Autophagy suppresses progression of K-ras-induced lung tumors to oncocytomas and maintains lipid homeostasis
Jessie Yanxiang Guo et al.
GENES & DEVELOPMENT (2013)
Discovery of RG7388, a Potent and Selective p53-MDM2 Inhibitor in Clinical Development
Qingjie Ding et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
A Potent Small-Molecule Inhibitor of the MDM2-p53 Interaction (MI-888) Achieved Complete and Durable Tumor Regression in Mice
Yujun Zhao et al.
JOURNAL OF MEDICINAL CHEMISTRY (2013)
p53 status determines the role of autophagy in pancreatic tumour development
Mathias T. Rosenfeldt et al.
NATURE (2013)
Mutational heterogeneity in cancer and the search for new cancer-associated genes
Michael S. Lawrence et al.
NATURE (2013)
Stapled α-helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy
Yong S. Chang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2013)
Identification of a second Nutlin-3 responsive interaction site in the N-terminal domain of MDM2 using hydrogen/deuterium exchange mass spectrometry
Lenka Hernychova et al.
PROTEOMICS (2013)
p53 increases MHC class I expression by upregulating the endoplasmic reticulum aminopeptidase ERAP1
Bei Wang et al.
NATURE COMMUNICATIONS (2013)
Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer
Yanying Huo et al.
CANCER DISCOVERY (2013)
p53 DNA Binding Cooperativity Is Essential for Apoptosis and Tumor Suppression In Vivo
Oleg Timofeev et al.
CELL REPORTS (2013)
Facilitates Chromatin Transcription Complex Is an Accelerator'' of Tumor Transformation and Potential Marker and Target of Aggressive Cancers
Henry Garcia et al.
CELL REPORTS (2013)
p53 Efficiently Suppresses Tumor Development in the Complete Absence of Its Cell-Cycle Inhibitory and Proapoptotic Effectors p21, Puma, and Noxa
Liz J. Valente et al.
CELL REPORTS (2013)
MDM2, MDMX and p53 in oncogenesis and cancer therapy
Mark Wade et al.
NATURE REVIEWS CANCER (2013)
Inhibition of RNA Polymerase I as a Therapeutic Strategy to Promote Cancer-Specific Activation of p53
Megan J. Bywater et al.
CANCER CELL (2012)
p53-Mediated Senescence Impairs the Apoptotic Response to Chemotherapy and Clinical Outcome in Breast Cancer
James G. Jackson et al.
CANCER CELL (2012)
Tumor Suppression in the Absence of p53-Mediated Cell-Cycle Arrest, Apoptosis, and Senescence
Tongyuan Li et al.
CELL (2012)
Insights into p53 transcriptional function via genome-wide chromatin occupancy and gene expression analysis
F. Nikulenkov et al.
CELL DEATH AND DIFFERENTIATION (2012)
A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumour growth through activation of p53
Qi Zhang et al.
EMBO MOLECULAR MEDICINE (2012)
An iTRAQ Proteomics Screen Reveals the Effects of the MDM2 Binding Ligand Nutlin-3 on Cellular Proteostasis
Judith Nicholson et al.
JOURNAL OF PROTEOME RESEARCH (2012)
Effect of the MDM2 antagonist RG7112 on the P53 pathway in patients with MDM2-amplified, well-differentiated or dedifferentiated liposarcoma: an exploratory proof-of-mechanism study
Isabelle Ray-Coquard et al.
LANCET ONCOLOGY (2012)
ATM and MET kinases are synthetic lethal with nongenotoxic activation of p53
Kelly D. Sullivan et al.
NATURE CHEMICAL BIOLOGY (2012)
MDM4 is a key therapeutic target in cutaneous melanoma
Agnieszka Gembarska et al.
NATURE MEDICINE (2012)
Protein-protein interaction inhibitors get into the groove
Asher Mullard
NATURE REVIEWS DRUG DISCOVERY (2012)
Activation of the p53 pathway by small-molecule-induced MDM2 and MDMX dimerization
Bradford Graves et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Lithocholic acid is an endogenous inhibitor of MDM4 and MDM2
Simon M. Vogel et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2012)
Human NK Cells Are Alerted to Induction of p53 in Cancer Cells by Upregulation of the NKG2D Ligands ULBP1 and ULBP2
Sonja Textor et al.
CANCER RESEARCH (2011)
Distinct p53 Transcriptional Programs Dictate Acute DNA-Damage Responses and Tumor Suppression
Colleen A. Brady et al.
CELL (2011)
PRIMA-1Met/APR-246 induces wild-type p53-dependent suppression of malignant melanoma tumor growth in 3D culture and in vivo
Wenjie Bao et al.
CELL CYCLE (2011)
Pharmacological activation of p53 triggers anticancer innate immune response through induction of ULBP2
Hai Li et al.
CELL CYCLE (2011)
Mechanism-specific signatures for small-molecule p53 activators
Ingeborg M. M. van Leeuwen et al.
CELL CYCLE (2011)
Abrogation of Wip1 expression by RITA-activated p53 potentiates apoptosis induction via activation of ATM and inhibition of HdmX
C. Spinnler et al.
CELL DEATH AND DIFFERENTIATION (2011)
A Phase I First-in-Human Pharmacokinetic and Pharmacodynamic Study of Serdemetan in Patients with Advanced Solid Tumors
Josep Tabernero et al.
CLINICAL CANCER RESEARCH (2011)
Novel Pyrrolopyrimidine-Based α-Helix Mimetics: Cell-Permeable Inhibitors of Protein-Protein Interactions
Ji Hoon Lee et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2011)
A Small-Molecule Inhibitor of MDMX Activates p53 and Induces Apoptosis
Hongbo Wang et al.
MOLECULAR CANCER THERAPEUTICS (2011)
The stress kinase MKK7 couples oncogenic stress to p53 stability and tumor suppression
Daniel Schramek et al.
NATURE GENETICS (2011)
Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3
M. H. Aziz et al.
ONCOGENE (2011)
Full p53 transcriptional activation potential is dispensable for tumor suppression in diverse lineages
Dadi Jiang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
Curaxins: Anticancer Compounds that Simultaneously Suppress NF-κB and Activate p53 by Targeting FACT
Alexander V. Gasparian et al.
SCIENCE TRANSLATIONAL MEDICINE (2011)
Adaptation of cancer cells from different entities to the MDM2 inhibitor nutlin-3 results in the emergence of p53-mutated multi-drug-resistant cancer cells
M. Michaelis et al.
CELL DEATH & DISEASE (2011)
Discovery of Mdm2-MdmX E3 Ligase Inhibitors Using a Cell-Based Ubiquitination Assay
Ariel G. Herman et al.
CANCER DISCOVERY (2011)
Rescue of p53 Function by Small-Molecule RITA in Cervical Carcinoma by Blocking E6-Mediated Degradation
Carolyn Ying Zhao et al.
CANCER RESEARCH (2010)
A Large Intergenic Noncoding RNA Induced by p53 Mediates Global Gene Repression in the p53 Response
Maite Huarte et al.
CELL (2010)
Rescue of the apoptotic-inducing function of mutant p53 by small molecule RITA
Carolyn Y. Zhao et al.
CELL CYCLE (2010)
Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53
C. F. Cheok et al.
CELL DEATH AND DIFFERENTIATION (2010)
Identification and Characterization of the First Small Molecule Inhibitor of MDMX
Damon Reed et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
SCH529074, a Small Molecule Activator of Mutant p53, Which Binds p53 DNA Binding Domain (DBD), Restores Growth-suppressive Function to Mutant p53 and Interrupts HDM2-mediated Ubiquitination of Wild Type p53
Mark Demma et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Novel Tryptamine Derivative JNJ-26854165 Induces Wild-Type p53-and E2F1-Mediated Apoptosis in Acute Myeloid and Lymphoid Leukemias
Kensuke Kojima et al.
MOLECULAR CANCER THERAPEUTICS (2010)
Cellular Metabolic Stress: Considering How Cells Respond to Nutrient Excess
Kathryn E. Wellen et al.
MOLECULAR CELL (2010)
Selective activation of p53-mediated tumour suppression in high-grade tumours
Melissa R. Junttila et al.
NATURE (2010)
Stage-specific sensitivity to p53 restoration during lung cancer progression
David M. Feldser et al.
NATURE (2010)
Role of Mdm4 in drug sensitivity of breast cancer cells
S. Lam et al.
ONCOGENE (2010)
Identification of Novel p53 Pathway Activating Small-Molecule Compounds Reveals Unexpected Similarities with Known Therapeutic Agents
Karita Peltonen et al.
PLOS ONE (2010)
Mitochondrial metabolism and ROS generation are essential for Kras-mediated tumorigenicity
Frank Weinberg et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2010)
The Control of the Metabolic Switch in Cancers by Oncogenes and Tumor Suppressor Genes
Arnold J. Levine et al.
SCIENCE (2010)
p53 post-translational modification: deregulated in tumorigenesis
Chao Dai et al.
TRENDS IN MOLECULAR MEDICINE (2010)
Ablation of Key Oncogenic Pathways by RITA-Reactivated p53 Is Required for Efficient Apoptosis
Vera V. Grinkevich et al.
CANCER CELL (2009)
MDM2-Dependent Downregulation of p21 and hnRNP K Provides a Switch between Apoptosis and Growth Arrest Induced by Pharmacologically Activated p53
Martin Enge et al.
CANCER CELL (2009)
HIPK2 Regulation by MDM2 Determines Tumor Cell Response to the p53-Reactivating Drugs Nutlin-3 and RITA
Cinzia Rinaldo et al.
CANCER RESEARCH (2009)
Identification of Nuclear Export Inhibitors with Potent Anticancer Activity In vivo
Sarah C. Mutka et al.
CANCER RESEARCH (2009)
Blinded by the Light: The Growing Complexity of p53
Karen H. Vousden et al.
CELL (2009)
Principles of Cancer Therapy: Oncogene and Non-oncogene Addiction
Ji Luo et al.
CELL (2009)
Modes of p53 Regulation
Jan-Philipp Kruse et al.
CELL (2009)
Activation of a unique p53-dependent DNA damage response
Jun Yang et al.
CELL CYCLE (2009)
p53-dependent inhibition of TrxR1 contributes to the tumor-specific induction of apoptosis by RITA
Elisabeth Hedstrom et al.
CELL CYCLE (2009)
Specific activation of the p53 pathway by low dose actinomycin D A new route to p53 based cyclotherapy
Meng Ling Choong et al.
CELL CYCLE (2009)
A panel of isogenic human cancer cells suggests a therapeutic approach for cancers with inactivated p53
Surojit Sur et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2009)
Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator
Sonia Lain et al.
CANCER CELL (2008)
SnapShot: p53 posttranslational modifications
Jan-Philipp Kruse et al.
CELL (2008)
Elevated MDM2 boosts the apoptotic activity of p53-MDM2 binding inhibitors by facilitating MDMX degradation
Mingxuan Xia et al.
CELL CYCLE (2008)
A novel p53 rescue compound induces p53-dependent growth arrest and sensitises glioma cells to Apo2L/TRAIL-induced apoptosis
L. Weinmann et al.
CELL DEATH AND DIFFERENTIATION (2008)
p53 Regulates Toll-Like Receptor 3 Expression and Function in Human Epithelial Cell Lines
Manabu Taura et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
Targeting tumor cells expressing p53 with a water-soluble inhibitor of Hdm2
Jirouta Kitagaki et al.
MOLECULAR CANCER THERAPEUTICS (2008)
Mdm2 Regulates p53 mRNA Translation through Inhibitory Interactions with Ribosomal Protein L26
Yaara Ofir-Rosenfeld et al.
MOLECULAR CELL (2008)
Transcriptional control of human p53-regulated genes
Todd Riley et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2008)
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
Sanjeev Shangary et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2008)
Identification of inhibitors for MDM2 ubiquitin ligase activity from natural product extracts by a novel high-throughput electrochemiluminescent screen
Christy A. Sasiela et al.
JOURNAL OF BIOMOLECULAR SCREENING (2008)
Cyclin-dependent kinase inhibitors sensitize tumor cells to nutlin-induced apoptosis: a potent drug combination
Chit Fang Cheok et al.
MOLECULAR CANCER RESEARCH (2007)
Quaternary structures of tumor suppressor p53 and a specific p53-DNA complex
Henning Tidow et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Reactivation of mutant p53: molecular mechanisms and therapeutic potential
G. Selivanova et al.
ONCOGENE (2007)
Reactivation of the p53 tumor suppressor pathway by a stapled p53 peptide
Federico Bernal et al.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY (2007)
Restoration of p53 function leads to tumour regression in vivo
Andrea Ventura et al.
NATURE (2007)
Senescence and tumour clearance is triggered by p53 restoration in murine liver carcinomas
Wen Xue et al.
NATURE (2007)
MDM2 inhibitors for cancer therapy
Lyubomir T. Vassilev
TRENDS IN MOLECULAR MEDICINE (2007)
Modeling the therapeutic efficacy of p53 restoration in tumors
Carla P. Martins et al.
CELL (2006)
Mdm2 is critically and continuously required to suppress lethal p53 activity in vivo
Ingo Ringshausen et al.
CANCER CELL (2006)
MDMX overexpression prevents p53 activation by the MDM2 inhibitor nutlin
Baoli Hu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Hdmx modulates the outcome of P53 activation in human tumor cells
Mark Wade et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Inactivation of the p53 pathway in retinoblastoma
Nikia A. Laurie et al.
NATURE (2006)
The structure of p53 tumour suppressor protein reveals the basis for its functional plasticity
Andrei L. Okorokov et al.
EMBO JOURNAL (2006)
The consensus coding sequences of human breast and colorectal cancers
Tobias Sjoeblom et al.
SCIENCE (2006)
The pathological response to DNA damage does not contribute to p53-mediated tumour suppression
M. A. Christophorou et al.
NATURE (2006)
Dual-site regulation of MDM2 E3-ubiquitin ligase activity
Maura Wallace et al.
MOLECULAR CELL (2006)
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
Diane Crighton et al.
CELL (2006)
Structure-based design of spiro-oxindoles as potent, specific small-molecule inhibitors of the MDM2-p53 interaction
Ke Ding et al.
JOURNAL OF MEDICINAL CHEMISTRY (2006)
Levels of HdmX expression dictate the sensitivity of normal and transformed cells to nutlin-3
JT Patton et al.
CANCER RESEARCH (2006)
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy
C Tovar et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
p53 in recombination and repair
S. A. Gatz et al.
CELL DEATH AND DIFFERENTIATION (2006)
hnRNP K: An HDM2 target and transcriptional coactivator of p53 in response to DNA damage
A Moumen et al.
CELL (2005)
The antioxidant function of the p53 tumor suppressor
AA Sablina et al.
NATURE MEDICINE (2005)
Small molecules that reactivate p53 in renal cell carcinoma reveal a NF-κB-dependent mechanism of p53 suppression in tumors
KV Gurova et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Temporal dissection of p53 function in vitro and in vivo
MA Christophorou et al.
NATURE GENETICS (2005)
Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells
BL Grasberger et al.
JOURNAL OF MEDICINAL CHEMISTRY (2005)
p53: a heavily dictated dictator of life and death
X Lu
CURRENT OPINION IN GENETICS & DEVELOPMENT (2005)
In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
LT Vassilev et al.
SCIENCE (2004)
Small molecule RITA binds to p53, blocks p53-HDM-2 interaction and activates p53 function in tumors
N Issaeva et al.
NATURE MEDICINE (2004)
Assay for ubiquitin ligase activity: High-throughput screen for inhibitors of HDM2
IV Davydov et al.
JOURNAL OF BIOMOLECULAR SCREENING (2004)
A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans
GL Bond et al.
CELL (2004)
Amplification of Mdmx (or Mdm4) directly contributes to tumor formation by inhibiting p53 tumor suppressor activity
D Danovi et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses
CP Rubbi et al.
EMBO JOURNAL (2003)
Rescue of mutants of the tumor suppressor p53 in cancer cells by a designed peptide
N Issaeva et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
p21/CDKN1A mediates negative regulation of transcription by p53
K Löhr et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Regulation of HDM2 activity by the ribosomal protein L11
MAE Lohrum et al.
CANCER CELL (2003)
Decision making by p53: life, death and cancer
M Oren
CELL DEATH AND DIFFERENTIATION (2003)
Selenomethionine regulation of p53 by a ref1-dependent redox mechanism
YR Seo et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2002)
BRCA1 directs a selective p53-dependent transcriptional response towards growth arrest and DNA repair targets
TK MacLachlan et al.
MOLECULAR AND CELLULAR BIOLOGY (2002)
Homeodomain-interacting protein kinase-2 phosphorylates p53 at Ser 46 and mediates apoptosis
G D'Orazi et al.
NATURE CELL BIOLOGY (2002)
Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound
VJN Bykov et al.
NATURE MEDICINE (2002)
C-terminal ubiquitination of p53 contributes to nuclear export
MAE Lohrum et al.
MOLECULAR AND CELLULAR BIOLOGY (2001)
Mdmx stabilizes p53 and Mdm2 via two distinct mechanisms
R Stad et al.
EMBO REPORTS (2001)
hSIR2SIRT1 functions as an NAD-dependent p53 deacetylase
H Vaziri et al.
CELL (2001)
ASPP proteins specifically stimulate the apoptotic function of p53
Y Samuels-Lev et al.
MOLECULAR CELL (2001)
Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53
J Parant et al.
NATURE GENETICS (2001)
Activation of p53 by roscovitine-mediated suppression of MDM2 expression
WG Lu et al.
ONCOGENE (2001)
A small synthetic peptide, which inhibits the p53-hdm2 interaction, stimulates the p53 pathway in tumour cell lines
P Chène et al.
JOURNAL OF MOLECULAR BIOLOGY (2000)
Share Paper
