Journal
FEBS LETTERS
Volume 588, Issue 8, Pages 1221-1229Publisher
WILEY
DOI: 10.1016/j.febslet.2014.01.031
Keywords
Autophagosome; Connexin; Gap junction; Lysosome; Proteasome; Ubiquitin
Funding
- National Institutes of Health [RO1-GM55725-13, RO1-EY08368]
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Connexin proteins are short-lived within the cell, whether present in the secretory pathway or in gap junction plaques. Their levels can be modulated by their rate of degradation. Connexins, at different stages of assembly, are degraded through the proteasomal, endo-/lysosomal, and phago-/lysosomal pathways. In this review, we summarize the current knowledge about connexin and gap junction degradation including the signals and protein- protein interactions that participate in their targeting for degradation. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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