Journal
FEBS LETTERS
Volume 588, Issue 8, Pages 1212-1220Publisher
WILEY
DOI: 10.1016/j.febslet.2014.01.013
Keywords
Connexin; Proteasome; Lysosome; Autophagy; Degradation; Trafficking
Funding
- American Heart Association [11POST5460028]
- Hawaii Community Foundation [11ADVC-49235]
- National Cancer Institute, National Institutes of Health [CA052098]
- National Center for Research Resources [2G12RR003061-26]
- National Institute on Minority Health and Health Disparities [8G12MD7601-27]
- Pacific Biosciences Research Center
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Intercellular communication can occur through gap junction channels, which are comprised of connexin proteins. Therefore, levels of connexins can directly correlate with gap junctional intercellular communication. Because gap junctions have a critical role in maintaining cellular homeostasis, the regulation of connexin protein levels is important. In the connexin life cycle, connexin protein levels can be modified through differential gene transcription or altered through trafficking and degradation mechanisms. More recently, significant attention has been directed to the pathways that cells utilize to increase or decrease connexin levels and thus indirectly, gap junctional communication. Here, we review the studies revealing the mechanisms that affect connexin protein levels and gap junctional intercellular communication. (c) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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