Journal
FEBS LETTERS
Volume 588, Issue 21, Pages 4032-4036Publisher
WILEY
DOI: 10.1016/j.febslet.2014.09.023
Keywords
Arachidonic acid; pfa gene; Polyunsaturated fatty acid; Polyunsaturated fatty acid synthase; Aureispira marina
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Arachidonic acid (ARA) is a polyunsaturated fatty acid (PUFA) and an essential component of membrane lipids. However, the PUFA synthase required for ARA biosynthesis has not been identified in any organism. To identify the PUFA synthase producing ARA, we determined the draft genome sequence of the marine bacterium Aureispira marina, which produces a high level of ARA, and found a gene cluster encoding a putative PUFA synthase for ARA production. Expression of the gene cluster in Escherichia coli induced production of ARA, demonstrating that the gene cluster encodes a PUFA synthase required for ARA biosynthesis. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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