Journal
FEBS LETTERS
Volume 588, Issue 4, Pages 574-583Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.12.026
Keywords
miR-98; Embryo implantation; Uterus; Rat; Bcl-xl
Funding
- Natural Science Foundation of China [81370720]
- National Research Institute for Family Planning [2012GJSSJKA03]
- International S&T Cooperation Program of China [2012DFB30130]
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In a previous study, via microRNA microarray analysis we found that miR-98 is differentially expressed in rat uteri during the peri-implantation period (unpublished data). However, the role of miR-98 in rat embryo implantation remains elusive. Here, we found that the level of miR-98 is lower on day 5 and 6 of gestation (g.d. 5-6) than that on g.d. 3-4 and g.d. 7-8 in rat. MiR-98 expression is significantly decreased by delayed implantation. Down-regulation of miR-98 promotes ESC proliferation and inhibits apoptosis. Up-regulation of miR-98 displays opposite effects. Further investigation revealed that miR-98 can bind to the 3'-untranslated region (3'-UTR) of B-cell lymphoma-extra large (Bcl-xl) to inhibit Bcl-xl translation. Collectively, down-regulation of miR-98 in rat uterus during the receptive phase is linked to the increase of cell proliferation via targeting Bcl-xl. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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