Journal
FEBS LETTERS
Volume 589, Issue 1, Pages 165-171Publisher
WILEY
DOI: 10.1016/j.febslet.2014.11.042
Keywords
Endotoxin; Lipid A; Mass spectrometry; Cytokine; Inflammation; Desulfovibrionaceae
Funding
- Agence Universitaire de la Francophonie (AUF)
- College doctoral Franco-Chinois
- Universite de Paris-Sud
- laboratory of Pr. Liping ZHAO at the University of Shanghai Jiaotong, China
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The levels of sulfate-reducing bacteria (SRB), including Desulfovibrionaceae, in the gut increase following a fat-enriched diet. Endotoxins from gut microbiota contribute to the inflammation process, leading to metabolic diseases. Thus, we sought to characterize the lipid A structures of Desulfovibrionaceae lipopolysaccharides (LPS) that are associated with the microbiota inflammatory properties. LPS variants were obtained from two SRB isolates from the gut of a single individual. These LPS variants shared similar lipid A moieties with Enterobacterial LPS, but differed from one another with regard to fatty-acid numbers and endotoxic activity. This first complete structural characterization of Desulfovibrio lipid A gives new insights into previously published data on Desulfovibrio lipid A biosynthesis. LPS microdiversity within SRBs illustrates how adaptation can influence pro-inflammatory potential. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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