Journal
FEBS LETTERS
Volume 588, Issue 23, Pages 4279-4286Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.09.025
Keywords
Inosine; Adenosine deaminase acting on tRNA; Transfer RNA; Deaminase; Codon usage; Evolution
Funding
- European Union's Seventh Framework Programme for research, technological development and demonstration [IRBPostPro 246557, IRBPostPro2.0 600404]
- Spanish Ministry of Economy and Innovation [BIO2012-32200]
- ICREA Funding Source: Custom
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Inosine on transfer RNAs (tRNAs) are post-transcriptionally formed by a deamination mechanism of adenosines at positions 34, 37 and 57 of certain tRNAs. Despite its ubiquitous nature, the biological role of inosine in tRNAs remains poorly understood. Recent developments in the study of nucleotide modifications are beginning to indicate that the dynamics of such modifications are used in the control of specific genetic programs. Likewise, the essentiality of inosine-modified tRNAs in genome evolution and animal biology is becoming apparent. Here we review our current understanding on the role of inosine in tRNAs, the enzymes that catalyze the modification and the evolutionary link between such enzymes and other deaminases. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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