Journal
FEBS LETTERS
Volume 588, Issue 7, Pages 1168-1177Publisher
WILEY
DOI: 10.1016/j.febslet.2014.02.054
Keywords
Gastric cancer; miR-145; miR-133a; miR-133b; Proliferation; Migration; Invasion; Cell cycle progression; Sp1
Funding
- National Natural Science Foundation of China [81171908]
- College graduate research and innovation projects of Jiangsu Province [CXZZ11_0729]
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MicroRNAs have recently emerged as key regulators of gastric cancers. Here we found that miR-145, miR-133a and miR-133b were down-regulated in gastric cancer tissues and cell lines. Overexpression of miR-145, miR-133a and miR-133b induced G1 cell cycle arrest and inhibited cell proliferation, migration and invasion in vitro. MiR-145, miR-133a and miR-133b targeted the transcription factor SP1, knockdown of which reduced the expression of MMP-9 and Cyclin D1 that were involved in cell growth and invasion. Thus, our findings demonstrated for the first time that miR-145, miR-133a and miR-133b suppressed the proliferation, migration, invasion and cell cycle progression of gastric cancer cells through decreasing expression of Sp1 and its downstream proteins. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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