Journal
FEBS LETTERS
Volume 589, Issue 3, Pages 396-406Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.12.026
Keywords
Enhancer RNA; Long non-coding RNA; NF-kappa B; Lipopolysaccharide; Monocyte; ERK and p38
Funding
- BBSRC [BB/K006223/1]
- BBSRC [BB/K006223/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/K006223/1] Funding Source: researchfish
Ask authors/readers for more resources
Recent studies have indicated that non-coding RNAs transcribed from enhancer regions are important regulators of enhancer function and gene expression. In this report, we have characterised the expression of six enhancer RNAs (eRNAs) induced in human monocytic THP1 cells following activation of the innate immune response by lipopolysaccharide (LPS). Specifically, we have demonstrated that LPS-induced expression of individual eRNAs is mediated through divergent intracellular signalling pathways that includes NF-kappa B and the mitogen activated protein kinases, extracellular regulated kinase-1/2 and p38. (C) 2014 The Authors. Published by Elsevier B.V.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available