Journal
FEBS LETTERS
Volume 588, Issue 9, Pages 1780-1786Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2014.03.038
Keywords
Long non-coding RNA; H19; Bcr-Abl; Tumorigenesis; c-Myc
Funding
- National Basic Research Program (973) of China [2014CB541804]
- Natural Science Foundation of China [81171943, U1305212]
- Chinese Academy of Sciences [KSZD-EW-L01-3]
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Dysregulation of non-coding RNA H19 has been observed in various tumors. However, it remains unknown whether H19 is involved in Bcr-Abl-induced leukemia. Here, we demonstrate a critical requirement for H19 in Bcr-Abl-mediated tumorigenesis. H19 was highly expressed in Bcr-Abl-transformed cell lines and primary cells derived from patients in a Bcr-Abl kinase-dependent manner. Silencing H19 expression sensitized leukemic cells to undergo imatinib-induced apoptosis and inhibited Bcr-Abl-induced tumor growth. Furthermore, H19 was shown to be regulated by c-Myc in Bcr-Abl-expressing cells. These results reveal an important role H19 plays in Bcr-Abl-mediated transformation and provide novel insights into complex mechanisms underlying Bcr-Abl-induced cancers. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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