Journal
FEBS LETTERS
Volume 588, Issue 12, Pages 2037-2041Publisher
WILEY
DOI: 10.1016/j.febslet.2014.04.028
Keywords
G protein-coupled receptor; Orphan GPCR; Drosophila; Bombyx; Neuropeptide
Funding
- GIST Systems Biology Infrastructure Establishment
- National Research Foundation of Korea - Ministry of Science, ICT and Future Planning (MSIP) [NRF-2011-0019291]
- Republic of Korea
- National Institutes of Health-United States [R01AI090062]
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To identify ligands for orphan GPCRs, we searched novel neuropeptide genes in the Drosophila melanogaster genome. Here, we describe CNMa, a novel cyclic neuropeptide that is a highly potent and selective agonist for the orphan GPCR, CG33696 (CNMaR). Phylogenetic analysis revealed that arthropod species have two paralogous CNMaRs, but many taxa retain only one. Drosophila CNMa potently activates CNMaR-2 from Apis mellifera, suggesting both receptors are functional. Although CNMa is conserved in most arthropods, Lepidoptera lack the CNMa gene. However, they retain the CNMaR gene. Bombyx CNMaR showed low sensitivity to Drosophila CNMa, hinting toward the existence of additional CNMaR ligand(s). (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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