Journal
FEBS LETTERS
Volume 588, Issue 17, Pages 3089-3097Publisher
WILEY
DOI: 10.1016/j.febslet.2014.06.037
Keywords
MicroRNA-30a; HCC; EMT; SNAI1
Funding
- National Natural Scientific Foundation of China [81072052, 81071897]
- Fundamental Research Funds for the Doctoral Program of Central College - Xi'an Jiaotong University
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The role of microRNA-30a (miR-30a) deregulation in tumor progression and its downstream signaling pathways remain unknown. Here we confirmed significant downregulation of miR-30a in hepatocellular carcinoma (HCC) tissues and cell lines compared with non-tumor counterparts. MiR-30a downregulation was significantly associated with worse disease-free survival (DFS) of HCC patients. Gain-and loss-of-function studies revealed that downregulation of miR-30a facilitated tumor cell migration, invasion and epithelial-mesenchymal transition (EMT). We identified SNAI1 as a direct target of miR-30a and demonstrated miR-30a as a novel regulator of EMT by targeting SNAI1, indicating its potential therapeutic value for reducing invasion and metastasis of HCC. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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