Journal
FEBS LETTERS
Volume 588, Issue 10, Pages 1913-1920Publisher
WILEY
DOI: 10.1016/j.febslet.2014.03.030
Keywords
microRNA-202; lipoprotein receptor-related protein 6; Proliferation; Hepatocellular carcinoma
Funding
- National Natural Science Foundation of China [30371394]
- Natural Science Fund of Hubei Province [2012FFA044]
- Health Department Found of Hubei Province [JX6B18]
- Public Service Platform Construction Projects of Wuhan Technology Bureau [2013060705010326]
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MicroRNAs have emerged as important regulators of carcinogenesis. In the current study, we observed that microRNA-202 (miR-202) is downregulated in hepatocellular carcinoma (HCC) cells and tissues, indicating a significant correlation between miR-202 expression and HCC progression. Overexpression of miR-202 in HCC cells suppressed cell proliferation and tumorigenicity, while downregulation of miR-202 enhanced the cells' proliferative capacity. Furthermore, we identified low-density lipoprotein receptor-related protein 6 (LRP6) as a direct target of miR-202. miR-202 suppresses the expression of LRP6 by binding to the 3 '-untranslated region (UTR) of its mRNA. Finally, we found that silencing the expression of LRP6 is the essential biological function of miR-202 during HCC cell proliferation. Collectively, our findings reveal that miR-202 is a potential tumor suppressive miRNA that participates in carcinogenesis of human HCC by suppressing LRP6 expression. (C) 2014 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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