Journal
FEBS LETTERS
Volume 588, Issue 5, Pages 720-726Publisher
WILEY
DOI: 10.1016/j.febslet.2014.01.015
Keywords
Cystatin; Interleukin-10; Lipopolysaccharide; Macrophage; MAP-kinase; Nitric oxide
Funding
- Slovenian Research Agency [J3-0612]
- Grant CEA France-Slovenia
- Slovenian Young researcher program
- [P-0140]
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Innate immune responses are tightly regulated to avoid excessive activation and subsequent inflammatory damage to the host, and interleukin-10 (IL-10) plays a crucial role in preventing inflammation. Stefin B (cystatin B) is an endogenous inhibitor of cysteine proteinases. In stefin B-deficient bone marrow-derived macrophages (BMDMs), we detected an increase in the induction of the LPS-induced pro-inflammatory signal nitric oxide (NO) but decreased IL-10 expression. The phosphorylation of ERK and p38 MAP-kinases was significantly decreased in stefin B-deficient macrophages, as was STAT-3 phosphorylation. These findings show that stefin B influences the expression of anti-inflammatory IL-10 in response to the TLR4 agonist LPS. (c) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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