Journal
FEBS LETTERS
Volume 588, Issue 9, Pages 1839-1849Publisher
WILEY
DOI: 10.1016/j.febslet.2014.03.048
Keywords
ppGpp; Stringent response; Intrinsically disordered region; RelA/SpoT; Mycobacteria
Funding
- Ministry of Human Resource Development, Govt. of India
- Council of Scientific and Industrial Research, Govt. of India
- IISER Bhopal
Ask authors/readers for more resources
The RelA/SpoT enzyme produces ( p) ppGpp that helps the bacterium survive during stress. The domains present in it are interspersed with connecting linkers whose functions have been poorly elucidated. We rationally analyzed the sequence and structural property of the regulatory C-terminal region in the Rel family of proteins and report the presence of an intrinsically disordered region between two successive domains in this region that are separated by a defined amino acid sequence length. We show that the length and secondary structure of this linker are conserved in Rel proteins, further signifying its importance in rendering flexibility for domain movement and domain-domain interaction. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available