Journal
FEBS LETTERS
Volume 587, Issue 17, Pages 2731-2737Publisher
WILEY
DOI: 10.1016/j.febslet.2013.06.026
Keywords
Evolution of metabolism; Metabolic pathway; Enzyme cluster; Reaction module; KEGG database
Funding
- Japan Science and Technology Agency
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There is a tendency that a unit of enzyme genes in an operon-like structure in the prokaryotic genome encodes enzymes that catalyze a series of consecutive reactions in a metabolic pathway. Our recent analysis shows that this and other genomic units correspond to chemical units reflecting chemical logic of organic reactions. From all known metabolic pathways in the KEGG database we identified chemical units, called reaction modules, as the conserved sequences of chemical structure transformation patterns of small molecules. The extracted patterns suggest co-evolution of genomic units and chemical units. While the core of the metabolic network may have evolved with mechanisms involving individual enzymes and reactions, its extension may have been driven by modular units of enzymes and reactions. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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