Journal
FEBS LETTERS
Volume 587, Issue 8, Pages 1206-1214Publisher
WILEY
DOI: 10.1016/j.febslet.2013.02.048
Keywords
Influenza A virus; Ribonucleoprotein complex; RNP; Nucleoprotein; NP; Structure; Assembly
Funding
- National Institutes of Health [AI077785]
- Robert A. Welch Foundation [C-1565]
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The genome of influenza A viruses consists of eight segments of single-stranded, negative-sense RNA that are encapsidated as individual rod-shaped ribonucleoprotein complexes (RNPs). Each RNP contains a viral RNA, a viral polymerase and multiple copies of the viral nucleoprotein (NP). Influenza A virus RNPs play important roles during virus infection by directing viral RNA replication and transcription, intracellular transport of the viral RNA, gene reassortment as well as viral genome packaging into progeny particles. As a unique genomic entity, the influenza A virus RNP has been extensively studied since the 1960s. Recently, exciting progress has been made in studying the RNP structure and its assembly, leading to a better understanding of the structural basis of various RNP functions. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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