Journal
FEBS LETTERS
Volume 587, Issue 14, Pages 2094-2098Publisher
WILEY
DOI: 10.1016/j.febslet.2013.05.051
Keywords
Prokaryotic cell; Crowding in vivo; Cytoplasm; Cytosol; Nucleoid; Cell envelope; Bio-macromolecular clustering; Localization; Diffusion; Vectorial transport; Coccoid cellular model
Funding
- Netherlands Science Foundation (NWO) [700.10.53, 728.011.104, 728.011.202]
- MCP Inc.
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We consider biomacromolecular crowding within the cytoplasm of prokaryotic cells as a two-phase system of 'supercrowded' cytogel and 'dilute' cytosol; we simplify and quantify this model for a coccoid cell over a wide range of biomacromolecular crowding. The key result shows that the supercrowded cytogel extends the vectorial character of the plasma membrane deeper into the cytoplasm by about 20-70 nm. We discuss useful physiological insights that this model gives into the functioning of a prokaryotic cell on the micrometer scale. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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