Journal
FEBS LETTERS
Volume 587, Issue 16, Pages 2682-2690Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.07.007
Keywords
Heterocyst differentiation; Ferric uptake regulator; Anabaena
Funding
- Ministerio de Ciencia e Innovacion, Spain [BFU2009-07424]
- Ministerio de Economia y Competitividad, Spain [BFU2012-31458]
- Diputacion General de Aragon (Obra Social La Caixa) [2009/0372]
- Universidad de Zaragoza/Banco Santander/Fundacion Carolina
- XXI Europe Program of Caja Inmaculada
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In Anabaena sp. PCC 7120, FurA is a global transcriptional regulator whose expression is strongly induced by NtcA in proheterocysts and remains stably expressed in mature heterocysts. In the present study, overexpression of furA partially suppressed heterocyst differentiation by impairing morphogenesis at an early stage. Recombinant purified FurA specifically bound in vitro to the promoter regions of ntcA, while quantitative RT-PCR analyses indicated that furA overexpression strongly affected the transient increase of ntcA expression that occurs shortly after nitrogen step-down. Overall, the results suggest a connection between iron homeostasis and heterocyst differentiation via FurA, by modulating the expression of ntcA. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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