Journal
FEBS LETTERS
Volume 587, Issue 9, Pages 1366-1372Publisher
WILEY
DOI: 10.1016/j.febslet.2013.03.007
Keywords
miR-16; IGF1R; Osteosarcoma
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Several miRNAs have been implicated in the development and progression of osteosarcoma (OS). In this study, we found that miR-16 is downregulated in OS cell lines and tissues. Overexpression of miR-16 suppresses OS cell proliferation and tumor growth in nude mice. Furthermore, we confirmed that IGF1R is a direct target of miR-16. Mechanistic investigation revealed that miR-16 overexpression inhibits the Raf1-MEK1/2-ERK1/2 pathway. In clinical specimens, IGF1R levels inversely correlate with miR-16 expression. Our results provide significant clues regarding the role of miR-16 as a tumor suppressor by targeting IGF1R in OS. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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