Journal
FEBS LETTERS
Volume 587, Issue 19, Pages 3261-3266Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.08.021
Keywords
COPII; Sec23; ERES; ER stress
Funding
- University of Salerno (FARB)
- Telethon [GSP08002, GGP06166]
- AIRC [IG 8623]
- Programma Operativo Nazionale (PON) [01_00862]
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Exit from the Endoplasmic Reticulum (ER) of newly synthesized proteins is mediated by COPII vesicles that bud from the ER at the ER Exit Sites (ERESs). Disruption of ER homeostasis causes accumulation of unfolded and misfolded proteins in the ER. This condition is referred to as ER stress. Previously, we demonstrated that ER stress rapidly impairs the formation of COPII vesicles. Here, we show that membrane association of COPII components, and in particular of Sec23a, is impaired by ER stress-inducing agents suggesting the existence of a dynamic interplay between protein folding and COPII assembly at the ER. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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