Journal
FEBS LETTERS
Volume 588, Issue 3, Pages 466-471Publisher
WILEY
DOI: 10.1016/j.febslet.2013.12.008
Keywords
Cyanobacteria; Nitrogen starvation; Rre37; 2-Oxoglutarate; Glycogen
Funding
- Ministry of Education, Culture, Sports, Science and Technology
- Core Research for Evolution Science and Technology, Japan
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Rre37 (sll1330) in a cyanobacterium Synechocystis sp. PCC 6803 acts as a regulatory protein for sugar catabolic genes during nitrogen starvation. Low glycogen accumulation in Delta rre37 was due to low expression of glycogen anabolic genes. In addition to low 2-oxoglutarate accumulation, normal upregulated expression of genes encoding glutamate synthases (gltD and gltB) as well as accumulation of metabolites in glycolysis (fructose-6-phosphate, fructose-1,6-bisphosphate, and glyceraldehyde-3-phosphate) and tricarboxylic acid (TCA) cycle (oxaloacetate, fumarate, succinate, and aconitate) were abolished by rre37 knockout. Rre37 regulates 2-oxoglutarate accumulation, glycogen accumulation through expression of glycogen anabolic genes, and TCA cycle metabolites accumulation. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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