Journal
FEBS LETTERS
Volume 587, Issue 18, Pages 2989-2995Publisher
WILEY
DOI: 10.1016/j.febslet.2013.07.018
Keywords
RBM20; DCM; Alternative splicing; Nuclear localization; Ribonucleoprotein; SR
Funding
- AIRC
- MIUR, Italy
Ask authors/readers for more resources
RBM20 is a nuclear protein which regulates alternative splicing of expressed genes that have a key role in cardiac function. By cloning the human and mouse RBM20 cDNA, producing expressing vectors for truncated proteins, and comparing their sub-cellular distribution in transfected cells, we have identified the sequences necessary for RBM20 full nuclear retention. The region overlaps an RNA binding motif and a serine-arginine domain. The sequence is conserved in many species but belongs only to RBM20 orthologs. The RMB20 tissue specificity, together with the properties of its nuclear localization determinant, demonstrates a specific evolutionary selection of post-transcriptional regulation factors. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available