Journal
FEBS LETTERS
Volume 587, Issue 10, Pages 1548-1555Publisher
WILEY
DOI: 10.1016/j.febslet.2013.01.075
Keywords
MicroRNA; Cardiomyocyte; Proliferation; Microarray; MicroRNA-29a
Funding
- Natural Science Foundation of China [81170130]
- National Basic Research Development Program in China (Program 973) [2010CB529505]
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Recent studies demonstrated that the mammalian heart possesses some capacity to proliferate. We observed cardiomyocyte proliferation within 4 weeks of age (P4W) in rats. We found 95 microRNAs that are differentially expressed in P4W cardiomyocytes. MicroRNA-29a was among the most highly up-regulated microRNAs in P4W cardiomyocytes. Overexpression of microRNA-29a suppressed the proliferation of H9c2 cell line. MicroRNA-29a inhibition induced cardiomyocytes to proliferate, accelerated the G1/S and G2/M transition, and up-regulated the cell cycle gene expression. Cyclin D2 (CCND2) was identified as a direct target of microRNA-29a. These findings indicate that microRNA-29a is involved in cardiomyocyte proliferation during postnatal development. Crown Copyright (C) 2013 Published by Elsevier B. V. on behalf of Federation of European Biochemical society. All rights reserved.
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