Journal
FEBS LETTERS
Volume 587, Issue 15, Pages 2299-2312Publisher
WILEY
DOI: 10.1016/j.febslet.2013.06.035
Keywords
Cohesin; Transcription; DNA repair; Condensation; Cohesinopathies; Meiosis
Funding
- DBT of the Government of India
- DST of the Government of India
- CSIR of the Government of India
- CSIR fellowships [09/087(0618)/2010-EMR-I, 09/087(0707)/2011-EMR-I]
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Faithful segregation of chromosomes during mitosis and meiosis is the cornerstone process of life. Cohesin, a multi-protein complex conserved from yeast to human, plays a crucial role in this process by keeping the sister chromatids together from S-phase to anaphase onset during mitosis and meiosis. Technological advancements have discovered myriad functions of cohesin beyond its role in sister chromatid cohesion (SCC), such as transcription regulation, DNA repair, chromosome condensation, homolog pairing, monoorientation of sister kinetochore, etc. Here, we have focused on such functions of cohesin that are either independent of or dependent on its canonical role of sister chromatid cohesion. At the end, human diseases associated with malfunctioning of cohesin, albeit with mostly unperturbed sister chromatid cohesion, have been discussed. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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