Journal
FEBS LETTERS
Volume 587, Issue 12, Pages 1731-1735Publisher
WILEY
DOI: 10.1016/j.febslet.2013.04.046
Keywords
Chemokine; CXCL14; CXCL12; CXCR4
Funding
- JSPS KAKENHI [23390256, 23659481, 22791043]
- MEXT KAKENHI [23126528]
- Mitsubishi Foundation
- Grants-in-Aid for Scientific Research [23659055, 23390256, 23126528, 23659481, 12J08863, 22791043] Funding Source: KAKEN
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Activation of the CXCL12-CXCR4 pathway is crucial for the migration of hematopoietic stem cells, various immune cells, and malignant tumor cells. Here, we show that another CXC chemokine, CXCL14, specifically binds to CXCR4 with high affinity and inhibits the CXCL12-mediated chemotaxis of human leukemia-derived cell lines and CD34(+) hematopoietic progenitor cells. Thus, CXCL14 functions as a natural inhibitor of CXCL12. Our observations suggest that CXCL14 represents, along with CXCR7, molecules that co-evolved with the CXCL12-CXCR4 axis to modulate important physiological processes in development, stem cell maintenance, and immune responses. Structured summary of protein interactions: CXCR4 physically interacts with CXCL14 anti bait coimmunoprecipitation by (View interaction). (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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