Journal
FEBS LETTERS
Volume 587, Issue 21, Pages 3548-3555Publisher
WILEY
DOI: 10.1016/j.febslet.2013.09.013
Keywords
Polysulfide; Nrf2; Keap1; Bound sulfur; Oxidative stress; Phosphorylation
Funding
- Grants-in-Aid for Scientific Research [23659089] Funding Source: KAKEN
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Polysulfide is a bound sulfur species derived from endogenous H2S. When mouse neuroblastoma, Neuro2A cells were exposed to tert-butyl hydroperoxide after treatment with polysulfide, a significant decline in cell toxicity was observed. Rapid uptake of polysulfides induced translocation of Nrf2 into the nucleus, resulting in acceleration of GSH synthesis and HO-1 expression. We demonstrated that polysulfide reversibly modified Keap1 to form oxidized dimers and induced the translocation of Nrf2. Moreover, polysulfide treatment accelerated Akt phosphorylation, which is a known pathway of Nrf2 phosphorylation. Thus, polysulfide may mediate the activation of Nrf2 signaling, thereby exerting protective effects against oxidative damage in Neuro2A cells. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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