Journal
FEBS LETTERS
Volume 588, Issue 1, Pages 41-46Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.10.046
Keywords
Koala; Gammaretrovirus; Promoter activity; Subgroup; Leukemia
Funding
- Ministry of Education, Culture, Science and Sports of Japan
- Japanese Society for the Promotion of Science [12J05135]
- Grants-in-Aid for Scientific Research [25891023, 12J05135] Funding Source: KAKEN
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Koala retrovirus (KoRV) is a gammaretrovirus which may induce immune suppression, leukemia and lymphoma in koalas. Currently three KoRV subgroups (A, B, and J) have been reported. Our phylogenetic analysis suggests that KoRV-B and KoRV-J should be classified as the same subgroup. In long terminal repeat (LTR), a KoRV-B isolate has four 17 bp tandem repeats named direct repeat (DR)-1, while a KoRV-J isolate (strain OJ-4) has three 37 bp tandem repeats named DR-2. We also found that the promoter activity of the KoRV-J strain OJ-4 is stronger than that of original KoRV-A, suggesting that KoRV-J may replicate more efficiently than KoRV-A. (C) 2013 Published by Elsevier B.V. on behalf of the Federation of European Biochemical Societies.
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