Journal
FEBS LETTERS
Volume 587, Issue 6, Pages 756-762Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.01.067
Keywords
Mitochondria; Metabolism; Inflammation; Cytokine
Funding
- NIH [NS014543, NS053898, GM49831, NS080177]
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Recent studies suggest a link between mitochondria and proinflammatory cytokine generation. We previously demonstrated that overexpression of mitochondrial chaperone glucose-regulated protein75 (Grp75/mortalin) protects mitochondria. In this study we investigated the modulation of the lipopolisaccharide (LPS)-induced inflammatory response of microglial BV-2 cells by Grp75. We demonstrate that LPS-induced activation promotes significant metabolic changes suppressing mitochondrial function and increasing glycolysis. Overexpression of Grp75 attenuates the LPS-induced oxidative and metabolic responses, and suppresses proinflammatory activation, which depends on both NF-kappa B activation and lactate. Thus overexpression of Grp75 provides a novel strategy to modulate proinflammatory cytokine production of relevance to inflammation-associated pathologies. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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