Journal
FEBS LETTERS
Volume 587, Issue 10, Pages 1524-1528Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2013.03.032
Keywords
TIMP-1; Erythroleukemic cell; Cell survival; Lyn
Funding
- Region Champagne-Ardenne
- Ligue Nationale contre le Cancer (comite de l'Aube)
- CNRS
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TIMP-1, a well-known MMP inhibitor, displays other biological activities such as cell survival, proliferation and differentiation in hematopoietic cells. In this report, we investigated the role of the Src-related kinase Lyn in TIMP-1 induced UT-7 erythroleukemic cell survival. We showed that (i) tyrosine 507 of Lyn was dephosphorylated and Lyn kinase activity enhanced by TIMP-1, (ii) Lyn silencing suppressed TIMP-1 anti-apoptotic activity and (iii) Lyn was activated upstream the JAK2/PI 3-kinase/Akt pathway. Our data suggest a novel role for Lyn in erythroid cell survival. (C) 2013 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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