Journal
FEBS LETTERS
Volume 586, Issue 15, Pages 2097-2105Publisher
WILEY
DOI: 10.1016/j.febslet.2012.04.061
Keywords
Rapamycin; Chemical dimerizer; Protein-protein interaction; Protein translocation; Signal transduction
Funding
- EMBL
- ESF [Schu 943/7-1]
- DFG [Transregio 83]
- Helmholtz Association
- German Lung Research Center
- EU
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In cell biology and pharmacology, small chemicals are mostly used as agonists and antagonists against receptors and enzymes. The immunosuppressant rapamycin can serve an entirely different purpose: if employed sensibly, it might function as an inducer of dimerization that is able to rapidly activate enzyme activity inside the intact cell. A number of very recent developments such as photoactivatable derivatives make rapamycin an even more attractive tool for basic science. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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