Perspective: Dynamics of receptor tyrosine kinase signaling complexes

Textbook descriptions of signal transduction complexes provide a static snapshot view of highly dynamic events. Despite enormous strides in identifying the key components of signaling complexes and the underlying mechanisms of signal transduction, our understanding of the dynamic behavior of these complexes has lagged behind. Using the example of receptor tyrosine kinases, this perspective takes a fresh look at the dynamics of the system and their potential impact on signal processing. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.