Journal
FEBS LETTERS
Volume 586, Issue 17, Pages 2586-2596Publisher
WILEY
DOI: 10.1016/j.febslet.2012.04.019
Keywords
Modular protein domain; Proteomics; Domainomics; Motif scanning; Domain scanning; Multiplex scanning
Funding
- Neag Comprehensive Cancer Center, American Cancer Society Institutional Research Grant
- NIH [RC1 CA146843, U01 CA154966]
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The ability of modular protein domains to independently fold and bind short peptide ligands both in vivo and in vitro has allowed a significant number of protein-protein interaction studies to take advantage of them as affinity and detection reagents. Here, we refer to modular domain based proteomics as domainomics to draw attention to the potential of using domains and their motifs as tools in proteomics. In this review we describe core concepts of domainomics, established and emerging technologies, and recent studies by functional category. Accumulation of domain-motif binding data should ultimately provide the foundation for domain-specific interactomes, which will likely reveal the underlying substructure of protein networks as well as the selectivity and plasticity of signal transduction. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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