Journal
FEBS LETTERS
Volume 586, Issue 14, Pages 1921-1928Publisher
WILEY
DOI: 10.1016/j.febslet.2012.03.063
Keywords
TGF-beta; Smad; Mathematical model; Dose-response; Switch-like response
Funding
- Excellence Initiative of the German Federal Government
- Excellence Initiative of the German State Government [EXC 294]
- NIGMS [T32GM08759]
- National Institutes of Health [R01GM083172, R01CA107098]
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The physiological responses to TGF-beta stimulation are diverse and vary amongst different cell types and environmental conditions. Even though the principal molecular components of the canonical and the non-canonical TGF-beta signaling pathways have been largely identified, the mechanism that underlies the well-established context dependent physiological responses remains a mystery. Understanding how the components of TGF-beta signaling function as a system and how this system functions in the context of the global cellular regulatory network requires a more quantitative and systematic approach. Here, we review the recent progress in understanding TGF-beta biology using integration of mathematical modeling and quantitative experimental analysis. These studies reveal many interesting dynamics of TGF-beta signaling and how cells quantitatively decode variable doses of TGF-beta stimulation. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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