Journal
FEBS LETTERS
Volume 586, Issue 15, Pages 2076-2083Publisher
WILEY
DOI: 10.1016/j.febslet.2012.02.038
Keywords
Synthetic biology; Riboswitch; Aptamer; Ribozyme; Aptazyme
Funding
- Else Kroner-Fresenius-Stiftung
- Aventis Foundation
- Deutsche Forschungsgemeinschaft
- LOEWE CGT
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Riboswitches are natural RNA-based genetic switches that sense small-molecule metabolites and regulate in response the expression of the corresponding metabolic genes. Within the last years, several engineered riboswitches have been developed that act on various stages of gene expression. These switches can be engineered to respond to any ligand of choice and are therefore of great interest for synthetic biology. In this review, we present an overview of engineered riboswitches and discuss their application in conditional gene expression systems. We will provide structural and mechanistic insights and point out problems and recent trends in the development of engineered riboswitches. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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