Journal
FEBS LETTERS
Volume 586, Issue 6, Pages 804-809Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.01.050
Keywords
MicroRNA; Cell cycle; Laryngeal carcinoma; Survivin
Funding
- National Natural Scientific Foundation of China [81030045, 30873006, 30901771]
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Previous studies have shown that miR-203 acts as a tumor-suppressive microRNA in various cancers, but its roles in laryngeal carcinoma are still contradicted. Here, we found that miR-203 inhibited the growth of laryngeal cancer cells and survivin was a direct target of miR-203. Moreover, silencing of survivin recapitulated the effect of miR-203 on cell cycle progression, whereas overexpression of survivin reversed this effect. Additionally, qRT-PCR showed the reciprocal relationship between miR-203 and survivin in laryngeal cancer tissues. These findings indicate that miR-203 inhibits the proliferation of laryngeal carcinoma cells by directly targeting survivin, suggesting its application in anti-cancer therapeutics. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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