Journal
FEBS LETTERS
Volume 586, Issue 10, Pages 1547-1554Publisher
WILEY
DOI: 10.1016/j.febslet.2012.04.021
Keywords
Short-chain fatty acid; GPR41; Sympathetic nervous system; Neurotransmitter release; Synapsin
Funding
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Japan Science and Technology Agency
- Yakult Bio-Science Foundation
- Institute for Fermentation, Osaka
- Grants-in-Aid for Scientific Research [20117008, 24659017, 24590077, 23659038] Funding Source: KAKEN
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Synapsins are neuronal phosphoproteins that coat synaptic vesicles and are believed to function in the regulation of neurotransmitter release. The signaling mechanism for short-chain free fatty acid (SCFA)-stimulated NE release was examined using primary-cultured mouse sympathetic cervical ganglion neurons. Pharmacological and knockdown experiments showed that activation of sympathetic neurons by SCFA propionate involves SCFA receptor GPR41 linking to G beta gamma-PLC beta 3-ERK1/2-synapsin 2 signaling. Further, synapsin 2b directly interacts with activated ERK1/2 and can be phosphorylated on serine when SCFA activates sympathetic neurons. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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