Journal
FEBS LETTERS
Volume 586, Issue 18, Pages 2932-2938Publisher
WILEY
DOI: 10.1016/j.febslet.2012.07.031
Keywords
Gene regulation; Pseudomonas; Efflux pumps; Energy generation
Funding
- Fondo Social Europeo
- European Union [BIO2010-17227]
- Junta de Andalucia Proyecto de Excelencia [CVI-3010]
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Pseudomonas putida strains are prevalent in a variety of pristine and polluted environments. The genome of the solvent-tolerant P. putida strain DOT-T1E which thrives in the presence of high concentrations of monoaromatic hydrocarbons, contains a circular 6.3 Mbp chromosome and a 133 kbp plasmid. Omics information has been used to identify the genes and proteins involved in solvent tolerance in this bacterium. This strain uses a multifactorial response that involves fine-tuning of lipid fluidity, activation of a general stress-response system, enhanced energy generation, and induction of specific efflux pumps that extrude solvents to the medium. Local and global transcriptional regulators participate in a complex network of metabolic functions, acting as the decision makers in the response to solvents. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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