Journal
FEBS LETTERS
Volume 586, Issue 20, Pages 3633-3638Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.08.009
Keywords
AKH; Corazonin; Myosuppressin; SIFamide; RNAi
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The Drosophila ATP7 copper transporter has sequence homology to the human copper transporters A'TP7A and ATP7B, which are defective in Menkes and Wilson disease, respectively. We show here that in Drosophila ATP7 is expressed by many peptidergic neurons. As C-terminal amidation of neuropeptides depends on the copper-containing enzyme PHM, it seemed likely that in the absence of ATP7 the activity of PHM might be compromised. Indeed, inhibition of ATP7 expression by RNAi led to a decrease in mature amidated neuropeptides and the appearance of C-terminally Gly-extended neuropeptides. The strength of this effect differed from one cell type to another, it was very pronounced for AKH and corazonin, but much less so for SIFamide and myosuppressin. Nevertheless, down-regulation of ATP7 specifically in the SIFamide-expressing neurons resulted in male-male courtship behavior. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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