Journal
FEBS LETTERS
Volume 586, Issue 23, Pages 4215-4222Publisher
WILEY
DOI: 10.1016/j.febslet.2012.10.025
Keywords
Transthyretin; Glucagon; Pancreas; Pancreatic alpha cell; Glucose homeostasis
Funding
- Advanced Education Program for Integrated Clinical, Basic and Social Medicine, Graduate School of Medical Sciences, Kumamoto University
- Amyloidosis Research Committee
- Pathogenesis, Therapy of Hereditary Neuropathy Research Committee
- Ministry of Health and Welfare of Japan
- Ministry of Education, Science, Sports and Culture of Japan [20253742]
- Graduate School of Medical Sciences, Kumamoto University, Japan
- Grants-in-Aid for Scientific Research [23659303] Funding Source: KAKEN
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Although transthyretin (TTR) is expressed in pancreatic alpha (glucagon) cells in the islets of Langerhans, the function of TTR in pancreatic alpha cells remains unknown. In this study, by using TTR knockout (TTR KO) mice, we determined the novel role of TTR in glucose homeostasis. We demonstrated that TTR KO mice evidenced impaired recovery of blood glucose and glucagon levels. Lack of TTR induced significantly lower levels of glucagon in the islets of Langerhans. These results suggest that TTR expressed in pancreatic alpha cells may play important roles in glucose homeostasis via regulating the expression of glucagon. (C) 2012 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.
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