Journal
FEBS LETTERS
Volume 586, Issue 22, Pages 4046-4051Publisher
WILEY
DOI: 10.1016/j.febslet.2012.10.005
Keywords
Junctional Adhesion Molecules; Melanoma metastasis; Adhesion
Funding
- ANR blanc
- Canceropole PACA
- Inserm Avenir
- Fondation pour la Recherche Medicale (FRM)
- Lilly Institute
- V. Frontera by Association pour la Recherche sur le Cancer (ARC)
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Metastasis is a major clinical issue and results in poor prognosis for most cancers. The Junctional Adhesion Molecule-C (JAM-C) expressed by B16 melanoma and endothelial cells has been involved in metastasis of tumor cells through homophilic JAM-C/JAM-C trans-interactions. Here, we show that JAM-B expressed by endothelial cells contributes to murine B16 melanoma cells metastasis through its interaction with JAM-C on tumor cells. We further show that this adhesion molecular pair mediates melanoma cell adhesion to primary Lung Microvascular Endothelial Cells and that it is functional in vivo as demonstrated by the reduced metastasis of B16 cells in Jam-b deficient mice. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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