Journal
FEBS LETTERS
Volume 586, Issue 20, Pages 3562-3568Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.febslet.2012.08.010
Keywords
KRAB domain; TRIM28; LTR; HIV-1; Zinc finger protein
Funding
- Japan Society for the Promotion of Science (JSPS), Japan
- Ministry of Health, Labor, and Welfare, Japan
- Strategic Research Foundation
- Ministry of Education, Culture, Sport, Science, and Technology, Japan (MEXT)
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The identification of cellular proteins that interact with the human immunodeficiency virus type 1 (HIV-1) long terminal repeat (LTR) provides a basic understanding of HIV-1 gene expression, which is the major determinant regulating virus replication. We show that ZBRK1 negatively regulates the HIV-1 LTR. Ectopic expression of ZBRK1 represses transcriptional activity of the HIV-1 LTR, whereas the depletion of endogenous ZBRK1 leads to activation of the HIV-1 LTR. The repressor activity of ZBRK1 is required for TRIM28 binding. Furthermore, ZBRK1 is bound to the HIV-1 LTR in vivo. These results indicate that ZBRK1 could be involved in a potent intrinsic antiretroviral defense.
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