Journal
FEBS LETTERS
Volume 587, Issue 1, Pages 73-81Publisher
WILEY
DOI: 10.1016/j.febslet.2012.11.004
Keywords
miR-137; Lung cancer; Cdc42; Cdk6
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MicroRNAs (miRNA) have emerged as key players in carcinogenesis. Here, we investigated the role of miR-137 in the pathogenesis of lung cancer. The downregulation of miR-137 in lung cancer cells could be rescued following inhibition of DNA methylation. Ectopic expression of miR-137 in lung cancer cells significantly downregulated Cdc42, Cdk6 and induced G1 cell cycle arrest, leading to a significant decrease in cell growth in vivo and in vitro. Further, both Cdc42 and Cdk6 were confirmed as targets of miR-137. Crown Copyright (C) 2012 Published by Elsevier B. V. on behalf of Federation of European Biochemical society. All rights reserved.
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